BISMUTH SUBCITRATE
Tripotassium Dicitrate Bismuthate
CAS: 57644-54-9
Molecular Formula: C6H9BiKO7
BISMUTH SUBCITRATE - Names and Identifiers
| Name | Tripotassium Dicitrate Bismuthate |
| Synonyms | de-nol de-noltab BISMUTH SUBCITRATE duosol(ulcertreatment) BISMUTH POTASSIUM CITRATE Bismuth Potassium Citrate tripotassiumdicitratobismuthate Tripotassium Dicitrate Bismuthate |
| CAS | 57644-54-9 |
| EINECS | 260-872-5 |
| InChI | InChI=1/2C6H8O7.Bi.3K/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;/q;;+3;3*+1/p-6 |
| InChIKey | ZQUAVILLCXTKTF-UHFFFAOYSA-H |
BISMUTH SUBCITRATE - Physico-chemical Properties
| Molecular Formula | C6H9BiKO7 |
| Molar Mass | 441.21 |
| Melting Point | >265°C (dec.) |
| Boling Point | 309.6°C at 760 mmHg |
| Flash Point | 155.2°C |
| Solubility | Water (Slightly) |
| Vapor Presure | 5.73E-05mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Merck | 14,2485 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
BISMUTH SUBCITRATE - Risk and Safety
| RTECS | TZ8492900 |
| Hazard Class | IRRITANT |
BISMUTH SUBCITRATE - Standard
Authoritative Data Verified Data
This product is a kind of bismuth containing complex with uncertain composition. The bismuth (Bi) content shall be between 35.0% and 38.5% based on the dry product.
Last Update：2024-01-02 23:10:35
BISMUTH SUBCITRATE - Trait
Authoritative Data Verified Data
- This product is white powder; There is moisture.
- This product is easily soluble in water and slightly soluble in ethanol.
Last Update：2022-01-01 13:39:16
BISMUTH SUBCITRATE - Differential diagnosis
Authoritative Data Verified Data
- take about 1 mg of this product, add 5M l of water to dissolve, add 2~3 drops of dilute sulfuric acid to acidify, and add several drops of 10% thiourea solution to show a dark yellow color.
- take about 0.lg of this product, add 5ml of water to dissolve, add 10 drops of perchloric acid solution (1-10), white precipitation occurs, separate precipitation, and the precipitate is insoluble in sodium hydroxide solution, dissolved in concentrated ammonia solution.
- take about 10mg of this product, add 0.2ml of water to dissolve, quickly add the newly prepared pyridine-acetic anhydride (3:1) about 5ml, the initial yellow, gradient to red or magenta.
Last Update：2022-01-01 13:39:16
BISMUTH SUBCITRATE - Exam
Authoritative Data Verified Data
pH
take 0.60g of this product, Add 10ml of water to dissolve, and then measure according to law (General rule 0631). The pH value should be 6.0~8.0.
sulfate
take this product l. After dissolving 20ml of water, add 4ml of dilute hydrochloric acid Dropwise, heat in a water bath for 10 minutes, let cool, filter, and divide the filtrate into 2 equal portions: add 5ml of 25% barium chloride solution to 1 portion and place it for 10 minutes, filter repeatedly until the filtrate is clear, dilute to 40ml with water, add 2.0ml of standard potassium sulfate solution, add appropriate amount of water to make it 50ml, shake well, and place for 10 minutes, as a control solution; after the other portion was diluted to 40ml with water, 5ml of 25% barium chloride solution was added, and then an appropriate amount of water was added to make it 50ml. The mixture was shaken well and left for 10 minutes. Compared with the control solution, it should not be more concentrated (0.04%).
nitrate
take 0.50g of this product, put it in a test tube, add 5ml of water to dissolve, add 5ml of sulfuric acid, mix well, cool, slowly add 5ml of ferrous sulfate test solution along the tube wall, two liquid layers shall be formed, and the interface shall not be immediately Brown.
loss on drying
take this product and dry it at 105°C for 5 hours, and the weight loss shall not exceed 5.0% (General rule 0831).
copper salt
take this product 0. 20g, add 2ml of water and 2ml of 10% ammonium gallate solution to dissolve, adjust the pH value of the solution to 8-9 with ammonia test solution, and add 5ml of 0.1% dicyclohexanone oxalyl dihydrazone dilute ethanol solution, then add water to make 50ml, such as color, with standard copper sulfate solution [weigh copper sulfate (CuS04 • 5H20 ) 0.393g, put in 1000ml measuring flask, add water to dissolve and dilute to the scale, shake; take 10ml, put it in a 100ml measuring flask, dilute it to scale with water, shake well, and compare with 0.50ml of control solution made by the same method, which is equivalent to 10ug of copper (Cu) per lml, not deeper (0.0025%).
lead salt
with this product l. After cooling, add 600 ~ 1.0ml of nitric acid Dropwise to dissolve the solution, evaporate on a water bath, cool, and add about 5ml of potassium hydroxide solution (1-6), bring the pH to 10 or more, boil for 2 minutes, cool, filter, wash the residue with a small amount of water, combine the wash with the filtrate, adjust the pH to 7 with acetic acid, dilute to 25ml with water, add 2ml of acetate buffer (pH 3.5) and 2ml of thioacetamide solution, shake well, and place for 2 minutes, such as color, and standard lead Solution 2.0ml of control solution prepared by the same method should not be deeper (0.002%).
ammonia content
take this product about lg, precision weighing, according to the nitrogen determination method (General 0704 first method), from "add water 40% slowly along the wall of the bottle" (change 75ml of sodium hydroxide solution to 30ml), determine according to law. Each 1 ml of sulfuric acid titration solution (0.05mol/L) corresponds to 1.703mg of NH3. Ammonia content should be 2% ~ 6%.
Last Update：2022-01-01 13:39:18
BISMUTH SUBCITRATE - Content determination
Authoritative Data Verified Data
take about 0.5g of this product, weigh it accurately, add 50ml of water to dissolve, add 3ml of nitric acid solution (l-3) and 2 drops of Xylenol Orange indicator solution, titrate with ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) until the solution yellow. Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) is equivalent to 10.45mg of Bi.
Last Update：2022-01-01 13:39:18
BISMUTH SUBCITRATE - Category
Authoritative Data Verified Data
gastric mucosal protective drugs.
Last Update：2022-01-01 13:39:18
BISMUTH SUBCITRATE - Storage
Authoritative Data Verified Data
light-shielded, sealed, and stored in a dry place.
Last Update：2022-01-01 13:39:18
BISMUTH SUBCITRATE - Bismuth Potassim Citrate Tablets
Authoritative Data Verified Data
This product contains bismuth potassium citrate Bismuth.(Bi) calculation, should be 90.0% ~ 110.0% of the label amount.
trait
This product is a white tablet or film-coated tablet, White after removing the coating.
identification
- take an appropriate amount of fine powder of this product (about 220mg of bismuth), add 50ml of water, fully stir, dissolve potassium bismuth citrate, filter, and test the filtrate according to the following method.
- take 1ml of filtrate, add 2-3 drops of dilute sulfuric acid for acidification, and add several drops of 10% thiourea solution, which is dark yellow.
- 10ml of the filtrate was taken, and 10 drops of the perchloric acid solution (1-10) were added, resulting in white precipitation.
- 0.2ml of the filtrate was taken, and 5ml of freshly prepared pyridine-acetic anhydride (3:1) was quickly added, which was initially yellow and gradually changed to red or magenta.
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
Take 20 tablets of this product, precise weighing, fine grinding, precise weighing appropriate amount (about 180mg equivalent to bismuth), add 50ml of water, fully shake to dissolve potassium bismuth citrate, then add 5ml of nitric acid solution (1-5) and 2 drops of Xylenol Orange indicator solution, and titrate with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) until the solution is yellow. 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) is equivalent to 10.45mg of Bi.
category
Same as bismuth potassium citrate.
specification
0.3g (equivalent to bismuth llOmg)
storage
shade, seal, and store in a cool place.
Last Update：2022-01-01 13:39:19
BISMUTH SUBCITRATE - Bismuth Potassium Citrate Capsules
Authoritative Data Verified Data
This product contains bismuth potassium citrate, calculated as bismuth (Bi), should be 90.0% ~ 110 of the label amount.
trait
The content of this product is white particles or powder.
identification
- take an appropriate amount of fine powder of this product (about 220mg of bismuth), add 50ml of water, fully stir, dissolve potassium bismuth citrate, filter, and test the filtrate according to the following method.
- take 1ml of filtrate, add 2-3 drops of dilute sulfuric acid for acidification, and add several drops of 10% thiourea solution, which is dark yellow.
- 10ml of the filtrate was taken, and 10 drops of the perchloric acid solution (1-10) were added, resulting in white precipitation.
- 0.2ml of the filtrate was taken, and 5ml of freshly prepared pyridine-acetic anhydride (3:1) was quickly added, which was initially yellow and gradually changed to red or magenta.
examination
should comply with the relevant provisions under the capsule (General rule 0103).
Content determination
take the contents under the difference of loading, mix evenly, weigh an appropriate amount (about 200mg of bismuth) accurately, add 18ml of dilute nitric acid, and fully shake to dissolve potassium bismuth citrate, add 50ml of water, mix well, add 3 drops of Xylenol Orange indicator solution, and titrate with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) until the solution is yellow. Each 1 ml of ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) corresponds to 10.45mg of BIS (Bi).
category
Same as bismuth potassium citrate.
specification
0.3g (bismuth-containing llOmg)
storage
light-shielded, sealed, and stored in a dry place.
Last Update：2022-01-01 13:39:20
BISMUTH SUBCITRATE - Bismuth Potassium Citrate Granules
Authoritative Data Verified Data
This product contains bismuth potassium citrate bismuth (Bi), should be 90.0% to 110.0% of the label.
trait
This product is white to light yellow particles.
identification
- take an appropriate amount of fine powder of this product (about 220mg of bismuth), add 50ml of water, fully stir, dissolve potassium bismuth citrate, filter, and test the filtrate according to the following method.
- take 1 ml of filtrate, add 2-3 drops of dilute sulfuric acid for acidification, and add several drops of 10% thiourea solution, which shows dark yellow color.
- 10 ml of the filtrate was taken, and 10 drops of the perchloric acid solution (1-10) were added, resulting in white precipitation.
- 0.2ml of the filtrate was taken, and 5ml of freshly prepared pyridine-acetic anhydride (3:1) was quickly added, which was initially yellow and gradually changed to red or magenta.
examination
- weight loss on drying this product shall be dried at 105°C to constant weight, and the weight loss shall not exceed 5.0% (General rule 0831).
- others should comply with the relevant provisions under The granule (General Principle 0104).
Content determination
The contents under the item of load difference were extracted, ground finely, and then an appropriate amount (about 180mg equivalent to bismuth) was accurately weighed. Add 50ml of water, and fully shake to dissolve potassium bismuth citrate, then nitric acid (1-5)5ml and Xylenol Orange indicator solution 2 drops, with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) titration until the solution yellow. Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) is equivalent to 10.45mg of Bi.
category
Same as bismuth potassium citrate.
specification
- each bag l.Og: containing bismuth llOmg
- 1.2g per bag: contains LB 1 Mg
storage
light-shielded, sealed, and stored in a dry place.
Last Update：2022-01-01 13:39:21
BISMUTH SUBCITRATE - Reference Information
| pharmacological action and mechanism | bismuth potassium citrate has a clear inhibitory effect on pepsin activity, but whether it can affect the secretion of pepsin is still controversial, and its role in neutralizing gastric acid is very weak. At present, it is believed that the role of bismuth potassium citrate is mainly to play a role locally. The specific mechanisms are as follows: ①Kill Helicobacter pylori (Hp) and reduce the pathogenic effect of Hp; ②Mucosal protection: strengthen the mucus barrier, non-specifically Inhibit the protease, lipase and glycosidase contained in Hp: Osmotic barrier effect, this product forms insoluble bismuth salt deposited on the gastric mucosa in an acidic environment, it is tightly combined with protein to form a bismuth peptide complex, which forms a protective film on the surface of the ulcer, which can isolate the erosion of gastric acid and enzymes on the ulcer, and has a protective effect on the gastric mucosa to prevent hydrogen ion infiltration. Stimulates endogenous prostaglandin synthesis. Stimulates the secretion of bicarbonate. When this product is applied for treatment, there is an accumulation of epidermal growth factor in the ulcer area. |
| indications | bismuth potassium citrate is suitable for gastric ulcer, duodenal ulcer, anastomotic ulcer, chronic gastritis, erosive gastritis, duodenitis, functional dyspepsia, gastric mucosal damage caused by non-steroidal anti-inflammatory drugs, and anti-Helicobacter pylori infection. |
| biological activity | Gastrodenol (Bismuth tripotassium dicitrate) is used to treat discomfort caused by excessive gastric acid, such as gastric ulcer and duodenal ulcer. |
| use | gastric medicine can promote the regeneration of epithelial cells and kill helicobacter pylori completely and persistently |
Last Update：2024-04-09 21:04:16
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Product Name: Gastrodenol Request for quotationCAS: 57644-54-9
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Product Name: Tripotassium Dicitrate Bismuthate Request for quotation
CAS: 57644-54-9
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CAS: 57644-54-9
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